A novel intermittent negative air pressure device ameliorates obstructive sleep apnea syndrome in adults.


The article is co-authored by Prof. Christian Guilleminault of Standard University.  


Thirty-five patients were enrolled: age 41.9 ± 12.2 years (mean ± standard deviation), BMI 26.6 ± 4.3 kg/m2, AHI 41.4 ± 24.3 events/hour, and oxygen-desaturation-index (ODI) 40.9 ± 24.4 events/hour at baseline. AHI and ODI were significantly decreased (p<0.001) by the device. Patients with moderate OSAS, with baseline AHI between 15 to 30 events/hour, achieved 64% response rate; and non-obese patients, with BMI below 25 kg/m2, achieved 57% response rate, with response rate defined as 50% reduction in AHI from baseline and treated AHI lower than 20.  


Keywords Obstructive sleep apnea syndrome . Sleep-disordered breathing . Apnea–hypopnea index . Intermittent negative air pressure . Intraoral device . Oral pressure therapy


How does the iNAP work?

During sleep, the iNAP sleep therapy system creates a negative pressure within the oral cavity itself. The negative pressure pulls the tongue towards the upper palate therefore pulling the soft palate forward (increasing the size of the oropharyngeal airway). This keeps the oropharynx patent during sleep therefore preventing apnea-hypopnea caused by restrictive breathing. Once pressure is achieved the pump stops until the seal is broken. 


iNAP is available to the following patients:

  • For a patient who has been diagnosed with OSA but failed or never started  treatment

  • For travel where the CPAP machine will not be taken

The new alternative  treatment for Obstructive Sleep Apnea.     


iNAP Sleep Apnea Therapy is a new oral negative pressure therapy designed to provide a comfortable and relaxed sleep experience for patients suffering from mild to moderate severe obstructive sleep apnea and snoring.


The iNAP eliminates the need for a Continuous Positive Airway Pressure mask (known as a CPAP), humidifier and pressurised air which a significant percentage of people can't tolerate.


Instead, the iNAP uses a discreet, soft oral interface with a pocket-sized console to ensure you're getting the best night's sleep.

The iNAP comes with a portable battery-powered console and has an easy-to-clean saliva container, making it a perfect travel companion for OSA patients. 

iNAP is an ultra portable solution with a 5-7 night built-in rechargeable battery designed to provide a comfortable sleep experience for patients suffering from mild to moderate Obstructive Sleep Apnea (OSA) and snoring. 


Obstructive Sleep Apnea

Are you or your relatives experienced


Hypersomnia, lack of concentration

Lost of Memory, Depression



Insomnia, Nocturia, Sleep disruption


<during Sleep>

Snoring, experience of Sleep Apnea

Choking, Gasping for air

If so, you might likely be suffering from

Obstructive Sleep Apnea,

also known as OSA

iNAP® Sleep Therapy System

A Great Sleep experience for patients to get high-quality and uninterrupted sleep every night

Do I have

Sleep Apnea?

Epworth Sleepiness Scale

The higher the score,

the higher the risk of suffering

Obstructive Sleep Apnea (OSA).