國際醫學論文研究

Sleep and Breathing

2019年,國際睡眠醫學重要期刊 Sleep & Breathing ,有一篇關於iNAP的醫學論文,其內容講述新穎的間歇性負壓睡眠呼吸裝置可改善成人阻塞性睡眠呼吸中止症。此篇論文是由建立全世界睡眠醫學權威的史丹佛大學教授 Christian Guilleminault 共同發表。

在這份研究中,醫師們使用iNAP®負壓呼吸器於各種年齡層的睡眠呼吸中止症(OSA)患者,其呼吸中止指數(AHI)包含輕度、中度、重重,並通過多導睡眠監測儀(PSG)測量療效。

 

與沒有治療時的基礎線相比,使用iNAP後呼吸中止指數(AHI)和睡眠缺氧指數(ODI)顯著降低。輕中度患者,有接近65%的人AHI下降至10以下。整體而言,52%的患者AHI能控制在10以下。

 

​資料來源: 2019 Sleep and Breathing: International Journal of the Science and Practice of Sleep Medicine.

Publication list

Journal Paper:

  1. T. C. Hung et al., “Building a model to precisely target the responders of a novel intermittent negative air pressure device-with mechanism definition”, Sleep Medicine, In  Press, 2020, https://doi.org/10.1016/j.sleep.2020.03.014
     

  2. T. C. Hung et al., “A novel intermittent negative air pressure device ameliorates obstructive sleep apnea syndrome in adults,” Sleep Breath., vol. 23, no. 3, pp. 849–856, 2019, http://doi.org/10.1007/s11325-018-01778-z
     

  3. Y. Yamaguchi and M. Kato, “Pilot Study of Oral Negative Pressure Therapy for Obstructive Sleep Apnea-Hypopnea Syndrome,” J. Sleep Disord. Ther., vol. 06, no. 03, 2017, http://doi.org/10.4172/2167-0277.1000271 
     

  4. M. Camacho, S. A. Song, and A. M. Tolisano, “Oral pressure therapy (winx) for obstructive sleep apnea: a meta-analysis updating the systematic review,” Sleep Breath., vol. 20, no. 3, pp. 1011–1012, 2016, http://doi.org/10.1007/s11325-016-1350-z 
     

  5. G. Nigam, C. Pathak, and M. Riaz, “Effectiveness of oral pressure therapy in obstructive sleep apnea: a systematic analysis,” Sleep Breath., vol. 20, no. 2, pp. 663–671, 2016, http://doi.org/10.1007/s11325-015-1270-3 
     

  6. R. J. Schwab et al., “Examining the Mechanism of Action of a New Device Using Oral Pressure Therapy for the Treatment of Obstructive Sleep Apnea,” Sleep, vol. 37, no. 7, pp. 1237–1247, 2014, http://doi.org/10.5665/sleep.3846 
     

  7. I. M. Colrain et al., “A multicenter evaluation of oral pressure therapy for the treatment of obstructive sleep apnea,” Sleep Med., vol. 14, no. 9, pp. 830–837, 2013,  http://doi.org/10.1016/j.sleep.2013.05.009 
     

  8. J. G. Park, T. M. Morgenthaler, and P. C. Gay, “Novel and emerging nonpositive airway pressure therapies for sleep apnea,” Chest, vol. 144, no. 6, pp. 1946–1952, 2013, http://doi.org/10.1378/chest.13-0273 
     

  9. M. Farid-Moayer, L. C. Siegel, and J. Black, “Oral pressure therapy for treatment of obstructive sleep apnea: Clinical feasibility,” Nat. Sci. Sleep, vol. 5, pp. 53–59, 2013,  http://doi.org/10.2147/NSS.S44736
     

  10. Farid-Moayer M, Siegel LC, Black J. A feasibility evaluation of oral pressure therapy for the treatment of obstructive sleep apnea. Ther Adv Respir Dis, 2013, 7:3-12. http://doi.org/10.1177/1753465812468043.
     

  11. D. A. Barone, “Alternative devices for obstructive sleep apnea,” Neurol. Clin. Pract., vol. 3, no. 1, pp. 67–70, 2013, http://doi.org/10.1212/CPJ.0b013e318278be88

Conference Paper:
 

  1. Georg N et al., A Multi-center, Two-stage, Single-arm, Prospective, First-night Order Cross-over, Evaluator-blind Study to Evaluate the Efficacy, Safety and Tolerance of the iNAP® Sleep Therapy System in Adults with Obstructive Sleep Apnea (OSA)--AN INTERIM ANALYSIS. 27th DGSM (Deutschen Gesellschaft für Schlafforschung und Schlafmedizin), 2019, Germany. 
     

  2. Liu CL et al., Intra-oral negative pressure therapy in patients with obstructive sleep apnea: upper airway imaging in responders vs. nonresponders.  Sleep DownUnder, 2019, Australia.
     

  3. Li HY et al., CPAP離脱者への対応 – How do we manage CPAP failure? 日本睡眠学会第44回定期学術集会, 2019, Japan.
     

  4. Lin CM et al., A Single-center Cross-over and Evaluator-blind Pivotal Study to Evaluate the Efficacy and Safety of intraoral Negative Air Pressure Device in Adults with Obstructive Sleep Apnea. 33rd Annual Meeting of the Associated Professional Sleep Society, 2019, United States.
     

  5. Liu TJ et al., Upper Airway Imaging of Patients with Obstructive Sleep Apnea under Treatment of a Novel Intra‐Oral Negative Pressure Device. 10th International Surgical Sleep Society Meeting, 2019, United States.
     

  6. Liu CL et al., The effective rationale of a novel intra-oral negative pressure device for obstructive sleep apnea. Sleep DownUnder, 2018, Australia.
     

  7. Liu TJ et al., Follow-up Reports on Intraoral Negative Air Pressure Device Treated Patients Underwent Obstructive Sleep Apnea Uvulopalatopharyngoplasty. 9th International Surgical Sleep Society Meeting, 2018, Germany.
     

  8. Hang LW et al., Treatment Outcomes and Safety of a Novel Intraoral Negative Air Pressure Device in the First-in-Man Study. 2nd Congress of Asian Society of Sleep Medicine, 2018, South Korea.
     

  9. Liu TJ et al., Imaging and Treatment Outcomes of the iNAP® Sleep Therapy System in the Feasibility Study in Taiwan. 14th Taiwan Japan Conference on Otolaryngology Head and Neck Surgery, 2017, Taiwan.
     

  10. Liu TJ et al., An Oral Negative Pressure Device for Treatment Obstructive Sleep Apnea (OSA). 25th DGSM (Deutschen Gesellschaft für Schlafforschung und Schlafmedizin), 2017, Germany.
     

  11. Lin CM et al., A Multicenter Pilot Study on the Indications of the Negative Pressure Sleep Therapy System for the Treatment of Obstructive Sleep Apnea. A Joint Congress of World Association of Sleep Medicine and World Sleep Federation, 2017, Czech Republic.
     

  12. Liu TJ et al., Imaging and Treatment Outcomes of the iNAP® Sleep Therapy System in the Feasibility Study in Taiwan. Network of Asia-Pacific Sleep Specialists, 2016, United States.
     

  13. Lin CM et al., Clinical Efficacy and Safety Evaluation of a Novel Negative Pressure Therapy System for Treatment of Obstructive Sleep Apnea Adult Patients. 4th International Pediatric Sleep Association Congress in conjunction with the 14th annual meeting of Taiwan Society of Sleep Medicine, 2016, Taiwan.
     

  14. Liu TJ et al., Safety and Effectiveness of Intraoral Pressure Gradient Device for Obstructive Sleep Apnea Patients. 6th World Congress on Sleep Medicine, 2015, South Korea.
     

  15. Liu TJ et al., Preliminary result of an oral negative pressure device for treatment obstructive sleep apnea (OSA). 13th Asia-Oceania ORL-HNS Congress, 2015, Taiwan.
     

  16. Emsellem HA et al., Safety and effectiveness of oral pressure therapy with a new oral interface. Sleep, 2014, 37(abstr suppl):A146(4017).
     

  17. Colrain IM et al., Safety and effectiveness of oral pressure therapy: 3-month treatment evaluation. Am J Respir Crit Care Med, 2013, 187:A2119. 
     

  18. Patel SR et al., Am J Respir Crit Care Med, 2013, 187:A3752.
     

  19. Colrain IM et al., Compliance with oral pressure therapy for treatment of obstructive sleep apnea. Sleep, 2013, 36(abstr suppl):A138(0391).
     

  20. Colrain IM et al., Oral pressure therapy for obstructive sleep apnea in subjects without prior treatment experience. Sleep, 2013, 36(abstr suppl):A175(0504).
     

  21. Colrain IM et al., Oral Pressure Therapy: a new treatment for obstructive sleep apnea. Sleep and Biological Rhythms, 2013, 11 (S2):29-30.
     

  22. Malhotra A, et al., Oral pressure therapy improves obstructive sleep apnea. Am J Respir Crit Care Med, 2012, 185:A6810.
     

  23. Schwab RJ et al., Mechanism of action of a novel device using oral pressure therapy (OPT) for the treatment of OSA. Am J Respir Crit Care Med, 2012, 185:A6811.
     

  24. Colrain IM et al., A multicentre evaluation of oral pressure therapy for the treatment of obstructive sleep apnoea: sleep architecture effects. J Sleep Res, 2012, 21(Suppl 1):P696.
     

  25. Colrain IM et al., A Multi-Centre Evaluation of Oral Pressure Therapy for the Treatment of Obstructive Sleep Apnoea. J Sleep Res 2012, 21(Suppl 1):P697.
     

  26. Schwab RJ et al., Examining the mechanism of action of a new device using oral pressure therapy for the treatment of obstructive sleep apnea. J Sleep Res, 2012, 21(Suppl 1):O310.

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