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A novel intermittent negative air pressure device ameliorates obstructive sleep apnea syndrome in adults
The article is co-authored by Prof. Christian Guilleminault of Standard University.
Thirty-five patients were enrolled: age 41.9 ± 12.2 years (mean ± standard deviation), BMI 26.6 ± 4.3 kg/m2, AHI 41.4 ± 24.3 events/hour, and oxygen-desaturation-index (ODI) 40.9 ± 24.4 events/hour at baseline. AHI and ODI were significantly decreased (p<0.001) by the device. Patients with moderate OSAS, with baseline AHI between 15 to 30 events/hour, achieved 64% response rate; and non-obese patients, with BMI below 25 kg/m2, achieved 57% response rate, with response rate defined as 50% reduction in AHI from baseline and treated AHI lower than 20.
Keywords Obstructive sleep apnea syndrome . Sleep-disordered breathing . Apnea–hypopnea index . Intermittent negative air pressure . Intraoral device . Oral pressure therapy